cholesterol drug may reduce COVID-19 severity?
Medications for cholesterol and high blood pressure help stabilize underlying diseases, and likely help patients recover from COVID-19, study authors said
Coronavirus patients taking statins prior to hospitalization substantially reduced their odds of in-hospital death and severe COVID-19, researchers found, confirming earlier findings. Statin drugs are frequently used to lower blood cholesterol levels and prevent cardiovascular disease.
A team of scientists from University of California San Diego School of Medicine published findings in PLOS ONE last week, analyzing anonymized records on over 10,500 hospitalized COVID-19 patients admitted across 104 U.S. hospitals between January-September 2020 and enrolled in the American Heart Association’s COVID-19 Cardiovascular Disease (CVD) Registry.
At the start of the pandemic, researchers speculated statins could act against COVID-19 through their “known anti-inflammatory effects and binding capabilities, which could potentially stop progression of the virus,” Lori Daniels, MD, lead study author, professor and director of the Cardiovascular Intensive Care Unit at UC San Diego Health, wrote in a news release. Statins upregulate the ACE-2 receptor to convert angiotensin and control blood pressure, however ACE-2 is also a doorway for the virus causing COVID-19. Medications for cholesterol and high blood pressure help stabilize underlying diseases, and likely boost patients’ odds of recovering from COVID-19 disease, study authors said.
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Patients were 66 years old on average, and most patients (71%) had high blood pressure, cardiovascular disease, or both. Over 80% of all patients taking statins were also taking at least one drug to treat high blood pressure, and patients taking either class of medication or both were typically older, female and had a number of health issues.
Results indicated patients taking a statin alone saw a 46% lower odds of death, and about 25% lower risk of developing severe COVID, versus patients on neither class of medication. Patients taking both a statin and anti-hypertensive dropped risk of death by 40%.
Does Common cholesterol drug may reduce COVID-19 severity?
Answer:- Yes, California San Diego School of Medicin’s scientists study base common cholesterol drug may reduce COVID-19 severity.
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